組織蛋白B,L及D在人類復發性肝癌中扮演的角色
Date Issued
2001-07-31
Date
2001-07-31
Author(s)
李伯皇
DOI
892314B002426
Abstract
HCC is one of the most malignancies in Asia countries and South Africa. However, up to
80% of patients with primary HCC will recur again within five years. To our knowledge, the
mechanism of HCC recurrence is still unclear. Cathepsins have been demonstrated in human
lymph nodes, kidney, spleen, liver, lung, brain, gastrointestinal tissues, heart and skeletal
muscle (5-7), especially Cathepsin B, L and D. Cathepsins were reported that played an
important role in mediating the passage of malignant cells through the basement membrane
by degrading collagen and elastin in the basal lamina resulting in invasion and metastasis. In
the present study we investigated the expression of Cathepsin B, L and D in human patients
with primary HCC and recurrent HCC by using of Western blotting. The result showed the
expression of Cathepsin L in recurrent HCCs was significantly higher than those from
primary HCCs in static. The tumor stage of recurrent HCCs was more advanced than of
primary HCCs, the lower expression of the Cathepsin L was. It revealed that Cathepsin L may
play an important role in human patients with HCC recurrence again.
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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