行政院國家科學委員會專題研究計畫成果報告:左心室輔助器的研製及動物試驗研究─心室輔助器血栓形成之探討與改進(3/3)

By using in vitro circulation system,
left ventricular assist device (LVAD) could
be tested with different rpm, pressure and
flow volume. After replaced with bovine
blood LVAD still could be tested in vitro.
Heparin with concentration of 0.5 IU/mL
was added into blood for LVAD in vitro test.
Although thrombosis could be found within
LVAD after in vitro test, the position of
thrombosis were not 100% identical to those
of in vivo test. The absence of systolic and
diastolic pressure in LVAD test system and
Heparin could not be degraded in testing
system were the major causes and need to be
improved in the future study. After
removal of the septum between upper
housing and lower housing, and
improvement of the corner of bottom,
thrombosis still could be observed.
Heparin could not be added into the LVAD
was the major cause. Calf survived until
Day 148 within in vivo study this year,
which means that the design of LVAD,
surgical procedure, and the experience of
after-care were pretty mature. After the
improvement of thrombosis getting better,
the clinical application will come soon.