Lysophosphatidic Acid Induces Mitogenesis But Not Inhibit Autophagy in Saccharomyces cerevisiae
Other Title
水解磷酸脂LPA促進酵母菌細胞分裂但未抑制細胞自噬之研究
Journal
Acta Zoologica Taiwanica
Journal Volume
14
Journal Issue
2
Start Page
151
End Page
152
ISSN
1019-5858
Date Issued
2004-10
Author(s)
Abstract
Lysophosphatidic acid (LPA) has been shown to be an important extra cellular signaling molecular in mammalian systems. It induces mitogenesis under certain stress. Autophagy is a catabolic membrane-trafficking phenomenon that occurs in response to dramatic changes in the nutrients available to yeast cells. It happens when cell cycles arrest contrary to LPA response. We hypothesize that LPA induces mitogenesis and inhibits autophagy in yeast. Our results indicate that LPA activates the mitogenesis but doesn't inhibit autophagy in yeast.
水解磷酸脂LPA爲哺乳動物細胞中一種重要的細胞外訊息傳遞分子，當細胞面臨生存壓力時能刺激多種細胞增生；細胞自噬則爲酵母菌細胞面臨生存壓力之反應，通常發生於細胞生長與分裂停滯的階段，和一般認爲LPA促進細胞分裂作用互爲拮抗。我們的假說認爲LPA處理會促進酵母菌增生，並對細胞自噬產生抑制；經我們研究發現LPA(1μM)處理確實能夠促進酵母菌細胞之增生，顯示早先經證實缺乏LPA受器之酵母菌仍然能夠以某種機制對LPA產生反應，但卻未顯著影響細胞自噬之活性。
Subjects
酵母菌
水解磷酸脂
autophagy
yeast
自噬
細胞分裂
Lysophosphatidic acid LPA
mitogenesis
Publisher
臺灣大學理學院動物學系
Type
journal article