Co-infection of dengue and Zika viruses mutually enhances viral replication in the mosquito Aedes aegypti
Journal
Parasites & vectors
Journal Volume
16
Journal Issue
1
Date Issued
2023-05-11
Author(s)
Abstract
The mosquito Aedes aegypti transmits two of the most serious mosquito-borne viruses, dengue virus (DENV) and Zika virus (ZIKV), which results in significant human morbidity and mortality worldwide. The quickly shifting landscapes of DENV and ZIKV endemicity worldwide raise concerns that their co-circulation through the Ae. aegypti mosquito vector could greatly exacerbate the disease burden in humans. Recent reports have indicated an increase in the number of co-infection cases in expanding co-endemic regions; however, the impact of co-infection on viral infection and the detailed molecular mechanisms remain to be defined.
Subjects
Aedes aegypti; Co-infection; Dengue virus; NS5 protein; Zika virus
SDGs
Type
journal article