Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells
Journal
Chemical Communications
Journal Volume
50
Journal Issue
46
Pages
6116-6119
Date Issued
2014
Author(s)
Abstract
We have synthesized and evaluated two self-immobilizing, turn-on fluorescent probes carrying a coumarin molecular framework for imaging intracellular human steroid sulfatase (STS) activity. The 8-fluoromethyl coumarin derivative, which gives stronger fluorescence response in the incubation study with STS preparations, was successfully applied to visualize STS activity in cells.
Type
journal article