Risk of Major Osteoporotic Fracture After Cardiovascular Disease: A Population-Based Cohort Study in Taiwan
Resource
J. Epidemiol., 23(2), 109-114
Journal
Journal of Epidemiology
Pages
109-114
Date Issued
2013
Date
2013
Author(s)
Lai, Shih-Wei
Liao, Kuan-Fu
Lai, Hsueh-Chou
Tsai, Pang-Yao
Lin, Cheng-Li
Chen, Pei-Chun
Sung, Fung-Chang
Abstract
Background: We investigated the association between cardiovascular disease (CVD) and the risk of major osteoporotic fracture in Taiwan.
Methods: Using the Taiwan National Health Insurance Database for the period 2000-2007, we classified 43 874 patients aged 50 years or older with newly diagnosed CVD (coronary artery disease, heart failure, cerebrovascular disease, or peripheral atherosclerosis) as the CVD group and 43 874 subjects without CVD (frequency-matched by sex, age, and date selected) as the non-CVD group. Incidence and hazard ratios (HRs) for major osteoporotic fracture of the spine, hip, humerus, and forearm/wrist were estimated for the period until the end of 2010.
Results: After adjustment for confounders, the overall BRs for major osteoporotic fracture were 1.24 (95% CI = 1.13, 1.36) in men with CVD and 1.18 (95% CI = 1.11, 1.25) in women with CVD, as compared with the non-CVD group. As compared with the non-CVD group, the adjusted BR for major osteoporotic fracture was highest among subjects with cerebrovascular disease (HR 1.31; 95% CI 1.23, 1.39), followed by those with heart failure (HR 1.18; 95% CI 1.11, 1.27), peripheral atherosclerosis (HR 1.12; 95% CI 1.04, 1.20), and coronary artery disease (HR 1.07; 95% CI 1.01, 1.12).
Conclusions: CVD is associated with risk of major osteoporotic fracture in men and women in Taiwan.
Subjects
atherosclerosis
cardiovascular disease
cerebrovascular disease
fracture
heart failure
SDGs
Other Subjects
aged; article; cardiovascular disease; cohort analysis; factual database; female; fragility fracture; human; incidence; male; middle aged; proportional hazards model; risk factor; Taiwan; Aged; Aged, 80 and over; Cardiovascular Diseases; Cohort Studies; Databases, Factual; Female; Humans; Incidence; Male; Middle Aged; Osteoporotic Fractures; Proportional Hazards Models; Risk Factors; Taiwan
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