Vesicant-type Reaction Due to Docetaxel Extravasation
Journal
Acta Dermato-Venereologica
Journal Volume
83
Journal Issue
6
Pages
467-468
Date Issued
2003
Author(s)
Abstract
A 65-year-old woman with stage IIIA lung adenocarcinoma had received a right middleand lowerbilobectomy followed by six cycles of chemotherapy with gemcitabine and cisplatin. Docetaxel was administered because of poor response to the previous therapy. The treatment schedule for each cycle was intravenous infusion of docetaxel for 30 min on days 1, 8 and 15. The dosage was 36 mg/m weekly for each injection. After the first administration on day 1, extravasation of docetaxel into the dorsum of her left hand occurred. Local injection with hydrocortisone and ice packing were administered at that time. The lesion persisted and mild painful swelling was noted afterwards. She received a second injection of docetaxel on the right hand one week later – a smooth process without any complications. An erythematous swelling with tenderness and bulla formation developed on the dorsum of her left hand several hours after the second injection on the other hand. The next day she visited the oncological clinic of our hospital. Under the impression of cellulites, a prescription of cephalexin, acetaminophen and tramadol was given after intravenous injection of cefazolin 1g. The skin lesion continued to progress and extended to the whole left hand. She presented to us 14 days after the extravasation insult. On cutaneous examination, one palm-sized, welldemarcated, erythematous and slightly violaceous patch with flaccid bulla formation was noted on the dorsum of her left hand (Fig. 1) extending slightly to the volar aspect of the thenar region. She had neither palpable lymph nodes over the left anticubital fossa and the left axilla nor any systemic toxic signs. The range of motion of the left wrist was limited by tenderness and severe oedema. A vesicant-type reaction of docetaxel extravasation was diagnosed. The patient was instructed to use topical betamethasone valerate cream and chloramphenicol ointment to suppress the inflammation and for wound care.
SDGs
Other Subjects
betamethasone valerate; cefalexin; cefazolin; chloramphenicol; cisplatin; docetaxel; gemcitabine; hydrocortisone; hydrocortisone acetate; ice; paracetamol; tetracycline; tramadol; aged; arm edema; blister; cancer combination chemotherapy; case report; cellulitis; clinical feature; desquamation; drug extravasation; dry skin; erythema; female; human; hyperpigmentation; letter; lobectomy; lung adenocarcinoma; medical examination; priority journal; skin inflammation; skin manifestation; treatment outcome; wound care; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Eruptions; Extravasation of Diagnostic and Therapeutic Materials; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lung Neoplasms; Risk Assessment; Skin Diseases, Vesiculobullous; Taxoids
Type
letter