Hepatitis B vims in the colostra of HBeAg-positive carrier mothers
Journal
Journal of Pediatric Gastroenterology and Nutrition
Journal Volume
17
Journal Issue
2
Pages
207-210
Date Issued
1993
Abstract
To investigate the amount of hepatitis B virus (HBV) in colostra of hepatitis B e antigen (HBeAg)-positive carrier mothers and the relationship of HBV amount between colostrum and maternal blood, 50 HBeAg-positive carrier mothers were recruited and studied for hepatitis B surface antigen (HBsAg) titer, HBeAg titer, and HBV-DNA concentration in their sera and colostra. According to the presence or absence of serai HBV-DNA determined by dot hybridization, these 50 HBeAg-positive carrier mothers could be divided into two groups: Group 1 (n = 28, HBV-DNA <0.04 ng/ml), and group 2 (n = 22, HBV-DNA 5=0.04 ng/ml). The co-lostral HBsAg and HBeAg titers were both significantly higher in group 2 than in group 1. In addition, both co-lostral HBsAg and HBeAg titers had positive correlation with each corresponding maternal blood. Although the colostral HBV-DNA was undetectable by dot hybridization, all were positive by polymerase chain reaction with Southern blot hybridization. Because HBV-DNA can be detected in all HBeAg-positive carrier mother’s milk, it reinforces the necessity of hepatitis B vaccination for the neonates born to these carrier mothers, particularly in countries with a high carrier rate. ? 1993 Raven Press, Ltd., New York.
SDGs
Other Subjects
hepatitis B surface antigen; hepatitis B(e) antigen; virus DNA; article; breast milk; colostrum; controlled study; disease carrier; female; hepatitis B; Hepatitis B virus; human; major clinical study; priority journal; vertical transmission; virus transmission; Base Sequence; Carrier State; Colostrum; DNA Primers; DNA, Viral; Electrophoresis, Agar Gel; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B Virus; Human; Molecular Sequence Data; Mothers; Nucleic Acid Hybridization; Polymerase Chain Reaction; Support, Non-U.S. Gov't; DNA viruses; Hepatitis B virus
Type
journal article