Effects of Nickel on Autonomic Regulation: Role of Oxidative Stress and Inflammation
Date Issued
2008
Date
2008
Author(s)
Hsueh, Tzu-Wei
Abstract
The components of ambient particle may induce not only pulmonary injury but also cardiovascular diseases. Epidemiology studies have observed that oxidative stress and inflammation may be associated with the alterations of heart rate variability, especially in some susceptible persons. But the mechanism of these associations is unclear. Spontaneously hypertensive rats (SHR) were compared with Wistar Kyoto (WKY) rats after nickel sulfate exposure. We investigated the difference of HRV change between SHR and WKY. Additionally, in order to establish the role of oxidative stress and inflammatory effect on HRV, we used N-acetylcysteine (NAC) and Celecoxib to modify the anti-oxidative and anti-inflammatory capability of SHR. This study was based on a self-control study design. We used telemetry transmitters and collected 72 hours ECG data after NiSO4 exposure. The parameters of HRV such as ANN, LnSDNN, and LnRMSSD were calculated from the ECG data. After NiSO4 exposure, we found that SHR had greater ANN change than WKY (p<0.05). After four doses of NAC and Celecoxib treatment, the alterations of ANN on SHR were reduced to the levels caused by WKY. In summary, nickel-induced HRV change may be caused by oxidative stress and inflammation. Further toxicological studies are needed to establish the mechanism of oxidative stress and inflammation affect on HRV.
Subjects
Heart rate variability
Nickel
Oxidative stress
Inflammation
SDGs
Type
thesis
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