Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients
Journal
BMC Nephrology
Journal Volume
17
Journal Issue
1
Pages
33
Date Issued
2016
Author(s)
Abstract
Background: Fetuin-A is known as a circulating inhibitor of vascular calcification. Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients is still uncertain. Methods: In the post-hoc study, we analyzed serum fetuin-A and biochemical factors (Ca, P, i-PTH, hsCRP, TG, LDL-C) in 50 hemodialysis patients, who completed a 48-week, open-Label, controlled randomized parallel-group study. 23 patients received sevelamer and 27 patients received calcium carbonate. Results: After the 48-week treatment, the sevelamer group had less serum calcium increment, less iPTH decrement, more ALK-P increment, more hsCRP decrement and more LDL-C decrement. There was no significant difference in the serum fetuin-A decrement between two groups. Decreased serum fetuin-A levels were found after 48-week treatment in both groups: from 210.61 (104.73) to 153.85 (38.64) ug/dl, P = 0.003 in sevelamer group, from 203.95 (107.87) to 170.90 (58.02) ug/mL, P =0.002 in calcium group. The decrement in serum fetuin-A (Δfetuin-A) levels was associated with ΔCa (ρ = - 0.230, P = 0.040), ΔiPTH (ρ = 0.306, P = 0.031) and Δalbumin (ρ = 0.408, P = 0.003), not associated with sevelamer use, ΔP and ΔhsCRP. Conclusion: After long-term sevelamer or calcium carbonate treatment, both groups of maintenance HD patients had lower serum fetuin-A levels. Serum levels of increased calcium, decreased iPTH and decreased albumin were associated with the serum fetuin-A decrement. ? 2016 Lin et al.
SDGs
Other Subjects
C reactive protein; calcium; calcium carbonate; fetuin A; low density lipoprotein cholesterol; parathyroid hormone; phosphorus; sevelamer; triacylglycerol; AHSG protein, human; C reactive protein; calcium; calcium carbonate; chelating agent; fetuin A; low density lipoprotein cholesterol; parathyroid hormone; phosphorus; sevelamer; triacylglycerol; abdominal pain; adult; alkaline phosphatase blood level; Article; clinical article; constipation; controlled study; end stage renal disease; female; hemodialysis patient; human; lipoprotein blood level; long term care; male; multicenter study; open study; parallel design; prospective study; protein analysis; protein blood level; protein function; randomized controlled trial; treatment duration; triacylglycerol blood level; aged; clinical trial; complication; hemodialysis; hyperphosphatemia; Kidney Failure, Chronic; metabolism; middle aged; procedures; treatment outcome; Aged; alpha-2-HS-Glycoprotein; C-Reactive Protein; Calcium; Calcium Carbonate; Chelating Agents; Cholesterol, LDL; Female; Humans; Hyperphosphatemia; Kidney Failure, Chronic; Male; Middle Aged; Parathyroid Hormone; Phosphorus; Renal Dialysis; Sevelamer; Treatment Outcome; Triglycerides
Publisher
BioMed Central
Type
journal article