Gliomatosis cerebri with spinal metastasis presenting with chronic meningitis in two boys
Journal
Journal of the Formosan Medical Association
Journal Volume
114
Journal Issue
9
Pages
886-890
Date Issued
2015
Author(s)
Abstract
Spinal cord involvement in gliomatosis cerebri (GC) is uncommon. We report two patients with GC, who initially presented with chronic meningitis and were treated with antituberculous drugs. Although tumor meningitis was suspected, due to the intractable clinical course, a correct diagnosis was established after performing a biopsy examination of the metastatic spinal lesion which was detected by magnetic resonance imaging (MRI). Cerebrospinal fluid examination, including cytology, should be performed repetitively for patients with chronic meningitis refractory to antibiotic treatment. Spinal MRI is necessary for the complete neurological workup, even when the patients do not show spinal symptoms. ? 2012.
SDGs
Other Subjects
carbamazepine; mannitol; methylprednisolone; phenobarbital; temozolomide; tuberculostatic agent; valproic acid; adolescent; antibiotic therapy; anticonvulsant therapy; Article; ascites; blurred vision; bradycardia; brain dysfunction; brain ventricle peritoneum shunt; cancer chemotherapy; carcinomatous peritonitis; case report; cerebrospinal fluid cytology; cerebrospinal fluid examination; child; computer assisted tomography; diagnostic accuracy; disease course; dizziness; electroencephalography; enzyme linked immunospot assay; epileptic discharge; facial nerve paralysis; glioblastoma; gliomatosis cerebri; headache; histopathology; human; human tissue; hydrocephalus; hypertension; hyporeflexia; intracranial pressure; lumbar puncture; male; multiple cycle treatment; multiple organ failure; neurologic examination; neurologic gait disorder; nuclear magnetic resonance imaging; paresthesia; pleocytosis; polymerase chain reaction; proprioception; school child; sensory dysfunction; spinal cord biopsy; spinal cord metastasis; tonic clonic seizure; treatment outcome; tuberculin test; tuberculous meningitis; tumor seeding; unconsciousness; unsteady gait; vomiting; biopsy; brain; Brain Neoplasms; drug therapy; meningitis; Neoplasms, Neuroepithelial; pathology; radiotherapy; secondary; Spinal Neoplasms; x-ray computed tomography; Adolescent; Biopsy; Brain; Brain Neoplasms; Child; Drug Therapy; Humans; Magnetic Resonance Imaging; Male; Meningitis; Neoplasms, Neuroepithelial; Radiotherapy; Spinal Neoplasms; Tomography, X-Ray Computed
Publisher
Elsevier
Type
journal article