A Human PBPK/PD Model to Assess Arsenic Exposure Risk Through Farmed Tilapia Consumption
Resource
Bulletin of Environmental Contamination and Toxicology 83 (1): 108-114
Journal
Bulletin of Environmental Contamination and Toxicology
Pages
108-114
Date Issued
2009
Date
2009
Author(s)
Ling, M.-P.
Abstract
The purpose of this study was to develop a biologically based risk assessment model for human health through consumption of arsenic (As) contaminated farmed tilapia (Oreochromis mossambicus) from blackfoot disease (BFD)-endemic area in Taiwan for estimating the consumption advice. We linked a physiologically based pharmacokinetic (PBPK) and a pharmacodynamic (PD) model to account for the exposure and dose-response profiles of As in human. Risk analysis indicates that consumption of farmed tilapia poses no significant threat from As-induced lung and bladder cancers. The predicted risk-based median consumption advice was no more than 5-17 meals month -1 (or 2-6 g day -1). ? 2009 Springer Science+Business Media, LLC.
SDGs
Other Subjects
Arsenic exposure; Assessment models; Blackfoot disease; Bladder cancers; Consumption advice; Dose response; Human health; PBPK/PD; Risk-based; Arsenic; Health risks; Physiological models; Risk assessment; Risk management; Risk perception; Safety factor; Risk analysis; arsenic; article; biological model; blackfoot disease; bladder cancer; cancer risk; carcinogenesis; dose response; food contamination; food intake; lung cancer; risk assessment; simulation; Taiwan; Tilapia; Animals; Arsenic; Arsenic Poisoning; Carcinogens, Environmental; Dose-Response Relationship, Drug; Environmental Exposure; Fisheries; Food Contamination; Humans; Lung Neoplasms; Models, Biological; Risk Assessment; Skin Neoplasms; Tilapia; Urinary Bladder Neoplasms; Water Pollutants, Chemical; Oreochromis mossambicus; Tilapia
Type
journal article
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