Effectiveness and Safety of High-Power Photoselective Vaporization for Benign Prostatic Hyperplasia
Date Issued
2009
Date
2009
Author(s)
Yang, Teng-Kai
Abstract
Background and objectives: Transurethral resection of the prostate (TURP) has been the most commonly used procedure for benign prostatic hyperplasia. Photoselective vaporization of the prostate (PVP) has been evolved as an alternative. Our objectives are to evaluate the effectiveness and safety of the new high power PVP procedure.ethods: The one hundred and fifteen patients were enrolled from a single hospital at the same period, and they choose the preferred procedure after the advantages and disadvantages were informed. The major outcomes include improvements of international prostatic symptom score (IPSS), IPSS quality of life scores, maximum flowrate and postvoided residuals, and multivariate models analysis with potential confounders adjustments were used to evaluate the strength of the relationships between the major outcomes and the 2 different procedures. The subgroup for age, body mass index, prostate volume and prostatic specific antigen were analyzed for interaction.esults: The basic demographics were listed, and the parameters including height, weight, education level and annual income were significantly different between the 2 groups. Compared to TURP, the PVP group had better outcomes in IPSS improvements(13.6 versus 11.7, P=0.046), quality of life score change (2.91 versus 2.5, P=0.034). After 12 months of follow up duration, the TURP group showed higher urethral stricture rates (3.3% versus 14.5%, P=0.033). The multivariate analysis resulted in, after adjusted, PVP was a prediction factor for IPSS improvements versus TURP(estimate coefficient=2.70, 95 confidence interval=0.71 – 4.69).. The subgroup analyses showed younger and high BMI patients receive greater IPSS effects after PVP therapyonclusions: Our results showed that PVP offers effectiveness for BPH and advantageous over TURP with regard to operative safety. The long term follow up is needed to evaluate the durability and possible morbidity.
Subjects
Photoselective vaporization of the prostate
international prostatic symptom score
effectiveness
safety
Type
thesis
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