A Pilot Study on Simultaneous Estimation of Cerebral Capillary Permeability to Glucose Using the Extended Patlak Method.
Journal
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Journal Volume
2025
Start Page
Conference code 217505
ISSN
2694-0604
Date Issued
2025-07
Author(s)
Abstract
This pilot study aimed to extend the Patlak method to estimate cerebral capillary permeability to glucose by incorporating the early phase of fluorine-18 fluoro-2-deoxyglucose kinetics in dynamic positron emission tomography. By using the experimental data acquired from human subjects and computer simulations, we demonstrated the feasibility of simultaneously assessing capillary permeability and metabolic uptake rate. Specifically, the derived parametric values were able to distinguish cortical gray matter, subcortical structures, and white matter, while reasonably agreeing with previously reported physiological ranges. The model fitting was robust at the levels of signal-to-noise ratio achievable with current clinical settings.Clinical Relevance- This study establishes the feasibility to simultaneously assess cerebral vascular supply and metabolic uptake of glucose.
Type
conference paper