The Role of Viral Reactivation in Drug Reaction with Eosinophilia and Systemic Symptoms and Other Cutaneous Adverse Drug Reactions (cADRs)
Journal
Current Dermatology Reports
Journal Volume
5
Journal Issue
1
Pages
5-11
Date Issued
2016-03-01
Author(s)
Abstract
Cutaneous adverse drug reactions (cADRs) encompass many types of clinical presentations, ranging from benign maculopapular eruption (MPE) to severe cutaneous adverse reactions (SCARs). The relationship between viral reactivation and drug eruptions has been widely observed and has provided a new direction for researchers to explore. In recent years, a number of studies have focused in particular on sequential human herpes virus (HHV) reactivation in drug reaction with eosinophilia and systemic symptoms (DRESS), and these studies have provided crucial evidence demonstrating that clinical presentations can be closely related to the dynamics of viral activity. The DRESS patients with long-term sequelae tended to present with viral activation, including sequential changes in serum cytokines, chemokines, and immune cells. Moreover, other cADRs might also be influenced by the reactivation of different viruses. In this study, we discuss recent progress in understanding the role of viral reactivation in cADRs and the possible pathomechanism underlying the drug-induced immune response. ? 2016, Springer Science+Business Media New York.
Subjects
DIHS; DRESS; HHV; Hypersensitivity; Stevens–Johnson syndrome
SDGs
Other Subjects
chemokine; cytokine; gamma interferon; gamma interferon inducible protein 10; immunoglobulin G; interleukin 1beta; interleukin 2; interleukin 6; tumor necrosis factor alpha; autoimmune thyroiditis; clinical feature; DRESS syndrome; Herpesviridae; human; Human herpesvirus 6; immune response; immunocompetent cell; insulin dependent diabetes mellitus; priority journal; regulatory T lymphocyte; Review; skin disease; Stevens Johnson syndrome; virus reactivation
Publisher
Current Medicine Group LLC 1
Type
review