高脂血症病患血管通透性之研究
Other Title
THE STUDY OF VASCULAR PERMEABILITY CHANGE
IN HYPERLIPIDEMIC PATIENTS
IN HYPERLIPIDEMIC PATIENTS
Date Issued
1998
Date
1998
Author(s)
吳造中
DOI
872314B002210
Abstract
Background. The transfer process in human arterial wall has been studied by only a few
investigators. Currently, there is still no widely accepted and clinically noninvasive method to
measure the systemic vascular permeability. In our previous study, we used fluorophotometry to
evaluate the vascular endothelial integrity in vivo in hyperlipidemic rabbits. The vascular
permeability change correlated well with the serum cholesterol level and occurred in the very early stage of atherosclerosis.
Purpose. To evaluate the status of blood-aqueous barrier (F60) and to define the significant
determinants of vascular permeability in human beings.
Methods and Results. Fifty-eight males and 74 female patients (aged 53.6 ±10.6 years) received
risk stratification, physical and blood chemistry examinatios. Fluorophotometry examination was
also performed in these hyperlipidemic patients. The F60 value was the lowest in the premenopausal
female, higher in male, and the highest in postmenopausal females. It was higher in the aged patients,
those with diabetes mellitus, or those with vascular diseases. However, the F60 value was lower in
the patients with HDL ≧ 60 mg/dl. The F60 value also correlated positively with the patients’ age,
number of risk factors, cholesterol , LDL, T-CHO/HDL, LDL/HDL, glucose, and HbA1c levels, and
correlated negatively with the HDL level. By multivariate stepwise linear regression analysis, the
vascular permeability value correlated significantly with the LDL/HDL ratio, age, diabetes mellitus,
and cholesterol level. Other risk factors or the serum TG level were not significant independent
predictors for the F60 value.
Conclusion. The vascular permeability could be evaluated noninvasively by fluorophotometry. It
was independently determined by the patients‘ lipid profile, age, and the existence of diabetes
mellitus in hyperlipidemic patients.
investigators. Currently, there is still no widely accepted and clinically noninvasive method to
measure the systemic vascular permeability. In our previous study, we used fluorophotometry to
evaluate the vascular endothelial integrity in vivo in hyperlipidemic rabbits. The vascular
permeability change correlated well with the serum cholesterol level and occurred in the very early stage of atherosclerosis.
Purpose. To evaluate the status of blood-aqueous barrier (F60) and to define the significant
determinants of vascular permeability in human beings.
Methods and Results. Fifty-eight males and 74 female patients (aged 53.6 ±10.6 years) received
risk stratification, physical and blood chemistry examinatios. Fluorophotometry examination was
also performed in these hyperlipidemic patients. The F60 value was the lowest in the premenopausal
female, higher in male, and the highest in postmenopausal females. It was higher in the aged patients,
those with diabetes mellitus, or those with vascular diseases. However, the F60 value was lower in
the patients with HDL ≧ 60 mg/dl. The F60 value also correlated positively with the patients’ age,
number of risk factors, cholesterol , LDL, T-CHO/HDL, LDL/HDL, glucose, and HbA1c levels, and
correlated negatively with the HDL level. By multivariate stepwise linear regression analysis, the
vascular permeability value correlated significantly with the LDL/HDL ratio, age, diabetes mellitus,
and cholesterol level. Other risk factors or the serum TG level were not significant independent
predictors for the F60 value.
Conclusion. The vascular permeability could be evaluated noninvasively by fluorophotometry. It
was independently determined by the patients‘ lipid profile, age, and the existence of diabetes
mellitus in hyperlipidemic patients.
Subjects
Hyperlipidemia
Vascular Permeability
Fluorophotometry
Blood-aqueous Barrier
SDGs
Publisher
臺北市:國立臺灣大學醫學院內科
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
872314B002210.pdf
Size
50.04 KB
Format
Adobe PDF
Checksum
(MD5):64faf586759fd7343f5f4388ddcda859