Construction of Through-Space Charge-Transfer Nanoparticles for Facilely Realizing High-Performance NIR-II Cancer Phototheranostics
Journal
Advanced Functional Materials
ISSN
1616-301X
1616-3028
Date Issued
2024-09-06
Author(s)
Ka‐Wai Lee
Yijian Gao
Shu‐Hua Chou
Yingpeng Wan
Allen Chu‐Hsiang Hsu
Ji‐Hua Tan
Yuqing Li
Zhiqiang Guan
Huan Chen
Shengliang Li
Chun‐Sing Lee
Abstract
Phototheranostics with second near-infrared (NIR-II) emissions show great potential for disease diagnosis and imaging-guided phototherapy owing to deep tissue penetration, high imaging resolution, and excellent tumor eradication. Recently, molecular conjugation engineering and J-aggregation have been used to construct organic NIR-II materials. However, these molecules generally have extensive conjugation and large molecular weight in the range of 700–1700 g mol−1, requiring complicated molecular design and synthesis. Herein, a NIR-II emissive through-space charge-transfer (TSCT) nanoparticle (NP) using short-conjugated donor-acceptor (D-A) molecules (TTP) is reported for high-performance bioimaging and cancer phototheranostics. Owing to the short conjugation of the TTP molecule with a small molecular weight of only 518 g mol−1, the TTP monomer possesses visible absorption and first near-infrared (NIR-I) emission. Upon forming NPs in water, the efficient TSCT between TTP monomers leads to significantly red-shifted absorption to the NIR-I and emission to the NIR-II region with a tail that extends to 1400 nm. TTP NPs are employed in NIR-II in vivo blood-vessel bioimaging and cancer phototheranostics successfully. This work introduces a facile strategy to construct NIR-II emissive NPs based on short-conjugated D-A molecules for high-performance biomedical applications.
Subjects
donor-acceptor molecules
NIR-II fluorescence imaging
organic small molecules
phototheranostics
through-space charge transfer
Publisher
Wiley
Type
journal article