Atg1在細胞自噬和細胞凋亡之探討
Induction of autophagy and apoptosis by Atg1 to promote cell death
Date Issued
2007
Date
2007
Author(s)
Tang, Hong-Wen
DOI
en-US
Abstract
Atg1 encodes a Serine/Threonine kinase. In yeast, studies have found the requirement for Atg1 kinase activity in both CVT and autophagy. Atg1 interacts with multiple components of the autophagic machinery, and multiple signaling pathways converge on Atg1 to regulate autophagy. Thus, Atg1 is likely to represent a nodal point for controlling multiple steps in the autophagic process in response to various stresses. However, in higher eukaryotes, the role of Atg1 is still unclear.
It has been shown that autophagy can induce cells death. However, the molecular mechanism underlying the autophagic cell death program is unclear. I have examined a potential role for Atg1 in cell death using Drosophila melanogaster as a model system. My results demonstrate that dAtg1 is sufficient to cause cell death due to the induction of autophagy and apoptosis. These findings provide a direct evidence that autophagy and apoptosis are interconnected. I have also identified a novel protein, dDlk. My results demonstrated that dDlk can induce cell death. The biochemical and genetic data reveal that dDlk interacts with dAtg1 and functions downstream of dAtg1-mediated cell death. Thus, dDlk may be an important downstream player in mediating dAtg1’s biological effects on promoting cell death. I am currently investigating whether dDlk is mediated by Atg1 and what is the biological function of Atg1 in cell death.
Subjects
Atg1
細胞自噬
細胞凋零
細胞死亡
果蠅
autophagy
apoptosis
cell death
Drosophila
Type
other
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