行政院國家科學委員會專題研究計畫期中進度報告:罹患慢性肺疾病之早產兒的神經發展與影響因素研究(1/3)
Date Issued
2004
Date
2004
Author(s)
鄭素芳
DOI
922314B002127
Abstract
There were three purposes of this study:
(1) to use the Neonatal Neurobehavioral
Examination- Chinese version (NNE-C) to
evaluate the neurobehavioral development in
premature infants with chronic lung disease
(CLD) and premature infants without CLD
during neonatal period, (2) to use the clinical
and roentgenographic scoring systems to
assess the severity of respiratory disease in
these infants, and to examine the relation
between the severity of respiratory disease
and the neurobehavioral performance, and (3)
to use the cranial ultrasonography and
magnetic resonance imaging to assess the
neural integrity of these infants, and to
examine the relation between neural lesions
and the neurobehavioral development. This
study included 11 premature infants with
CLD and 12 premature infants without CLD.
The infants were administered the clinical
and roentgenographic scoring systems,
cranial ultrasonography and magnetic
resonance imaging, and the NNE-C during
neonatal period. The results showed that the
infants with CLD manifested lower NNE-C
scores at PCA 35-37 weeks and 38-42 weeks
than those without (p<0.01). The infants with
CLD showed higher clinical scores of
respiratory disease on day 14 and 28, and
higher roentgenographic scores on only day
28 compared with those without (p<0.001).
The neural imaging examinations revealed
that higher proportions of the infants with
CLD had neural lesions (p<0.01). Univariate
regression analysis showed that the severity
of respiratory disease and neural lesions each
had significant relations with the NNE-C
scores during neonatal period (R2 = 0.40-0.56
and R2 = 0.23-0.44, p< 0.01). Our
preliminary results suggest that respiratory
insufficiency, neural lesions and other factors
may contribute to the neurodevelopmental
outcome during neonatal period in infants
with CLD.
Subjects
早產兒
慢性肺疾病
神經發展
影響因子
Publisher
臺北市：國立臺灣大學醫學院物理治療學系暨研究所
Type
journal article
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