Antiplatelet activity of N-methoxycarbonyl aporphines from Rollinia mucosa
Journal
Phytochemistry
Journal Volume
57
Journal Issue
3
Pages
421-425
Date Issued
2001
Author(s)
CHE-MING TENG
Abstract
Bioassay-directed fractionation of the stems of Rollinia mucosa led to the isolation of new N-methoxycarbonyl aporphine alkaloids, romucosine A (1), romucosine B (2), romucosine C (3), and romucosine D (4), along with the known alkaloid, N-methoxylcarbonyl-nornuciferine (5). Alkaloids 1 and 4 exhibited significant inhibition of collagen, arachidonic acid, and platelet activating factor-induced platelet aggregation, and alkaloid 3 also showed an inhibitory effect on arachidonic acid induced platelet aggregation.
Type
journal article