High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model
Journal
Optics Express
Journal Volume
19
Journal Issue
22
Pages
21552-21562
Date Issued
2011
Author(s)
Lu J.-T.
Kuo C.-C.
Fu S.-C.
Tsai Y.-F.
Chuang E.Y.
Hwang Y.-J.
Abstract
We performed in vivo THz transmission imaging study on a subcutaneous xenograft mouse model for early human breast cancer detection. With a THz-fiber-scanning transmission imaging system, we continuously monitored the growth of human breast cancer in mice. Our in vivo study not only indicates that THz transmission imaging can distinguish cancer from the surrounding fatty tissue, but also with a high sensitivity. Our in vivo study on the subcutaneous xenograft mouse model will encourage broad and further investigations for future early cancer screening by using THz imaging system. ? 2011 Optical Society of America.
SDGs
Other Subjects
Imaging systems; Mammals; Tissue; Early cancer; High sensitivity; Human breast cancer; In-vivo; Mouse models; Transmission imaging; Diseases; absorption; animal; article; Bagg albino mouse; breast tumor; diagnostic imaging; drug screening; early diagnosis; female; human; methodology; mouse; nuclear magnetic resonance imaging; pathology; spectroscopy; subcutaneous tissue; Absorption; Animals; Breast Neoplasms; Diagnostic Imaging; Early Detection of Cancer; Female; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Spectrum Analysis; Subcutaneous Tissue; Xenograft Model Antitumor Assays
Type
journal article