高脂血症對心肌微循環血管屏障的影響及其在缺血—再灌流傷害中之角色

Abstract

Hypercholesterolemia (HC) is associated with atherosclerosis in systemic arteries. Its impacts on microcirculatory disturbances are receiving rigorous investigations. In this study, we used the cholesterol-enrich diet to treat the rabbit. The dynamic contrast-enhanced magnetic resonance imaging showed that the induced hypercholesterolemia was associated with increase in permeability surface area product but did not influence the myocardial blood flow. The pathological examination of those hypercholesterolemic rabbits delineated greater density of isolectin- and smooth muscle α -actin bound microvessels. Patchy expression of VEGF in perivascular and interstitial space of myocardium was also noted. Hypercholesterolemia was associated with increased coronary leakage without evident perfusion defect. Increased microvessel density, either pericyte-bound or not, suggested microvascular remodeling. VEGF could be induced in the setting and served as a possible underlying mechanism.