Blood Perfusion of Vertebral Lesions Evaluated with Gadolinium-Enhanced Dynamic Mri: In Comparison with Compression Fracture and Metastasis
Resource
JOURNAL OF MAGNETIC RESONANCE IMAGING v.15 n.3 pp.308-314
Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Journal Volume
v.15
Journal Issue
n.3
Pages
308-314
Date Issued
2002
Date
2002
Author(s)
CHEN, WEI-TSUNG
SHIH, TIFFANY TING-FANG
CHEN, RAN-CHOU
LUO, HSIN-YEN
Abstract
PURPOSE: To investigate blood perfusion of vertebral lesions using dynamic Gd-DTPA-enhanced MRI. MATERIALS AND METHODS: Dynamic MR studies were performed for cases of acute compression fracture, chronic compression fracture, metastatic vertebral lesions with or without compression fracture. A total of 42 patients (71 vertebral segments) were included. Five types of time-intensity curves (TICs) were defined as: nearly no enhancement (type A), slow enhancement (type B), a rapid contrast wash-in followed by an equilibrium phase (type C), a rapid contrast wash-in followed by early wash-out (type D), and a rapid contrast wash-in with a second slower-rising slope (type E). RESULTS: Metastatic vertebral lesions with or without fracture had a higher peak enhancement percentage and steeper enhancement slope than those of chronic compression fracture, but had no difference as compared to those of acute compression fracture. The type D curve had high positive predictive value for metastatic group (100%), and the type E curve had high positive predictive value for benign compression fracture (85.7%). CONCLUSION: Type D and E curves are valuable in the differentiation of benign and malignant vertebral lesions.
Subjects
Contrast Media
Gadolinium DTPA
Magnetic Resonance Imaging
Spinal Fractures
Spine
Neoplasm Metastasis