Comparison of analgesic effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy
Date Issued
2008
Date
2008
Author(s)
Tsai, Teng-Yu
Abstract
Objective To compare the systemic analgesic effects of intravenous lidocaine, meloxicam, and their combination in dogs undergoing ovariohysterectomy. Study design Randomized, double blind, controlled clinical trial.nimals Twenty-seven dogs aged 16.4 ± 6.9 months and weighing 22.4 ± 17.6 kg.ethods Twenty-seven healthy dogs scheduled for ovariohysterectomy were randomly divided into 3 groups (n = 9): Meloxicam (M) group, which was given with 0.2 mg/kg intravenous (IV) meloxicam and consecutively with Lactated Ringer’s infusion at 10 ml/kg/hr; Lidocaine (L) group, which received a bolus of lidocaine (1 mg/kg IV) followed by a lidocaine infusion (0.025 mg/kg/min IV); and Lidocaine + Meloxicam (M + L) group, which was given with a combination of 0.2 mg/kg meloxicam and 1 mg/kg lidocaine intravenously and followed with a lidocaine infusion (0.025 mg/kg/min). Anesthesia was induced with propofol and maintained with isoflurane in oxygen. Serum cortisol and glucose concentrations were measured preoperatively and at 0, 1, 2, 4, 8, 12 hours after extubation (t = 0). Three different pain scores were assessed by three independent observers unaware of analgesic protocols used at t 0, 1, 2, 4, 8, and 12. Any dog with a total subjective pain score exceeding 9 (with the maximum possible of 24) or any sub-score above 3 in any one category received rescue analgesic (fentanyl 3 μg/kg IV) and was excluded from further data analysis.esults There was no significant differences in subjective pain scores, serum cortisol, and glucose concentrations within the three groups. No dogs received rescue analgesics in the study. Neither meloxicam, liodcaine infusion, nor of their combination caused any observable side effect.onclusion and clinical relevance This study suggests that the intravenous lidocaine and meloxicam provide similar analgesic effect in healthy dogs undergoing ovariohysterectomy. No significant additive or synergic analgesic effect was observed in combination of the agents.eywords dog, analgesia, lidocaine, meloxicam, ovariohysterectomy.
Subjects
dog
analgesia
ovariohysterectomy
Type
thesis
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