Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer
Journal
Current Drug Targets
Journal Volume
13
Journal Issue
13
Pages
1649-1653
Date Issued
2012
Author(s)
Abstract
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.
SDGs
Type
journal article