HLA polymorphism among Chinese patients with chronic plaque psoriasis: Subgroup analysis
Journal
British Journal of Dermatology
Journal Volume
166
Journal Issue
2
Pages
288-297
Date Issued
2012
Author(s)
Abstract
Summary Background HLA-Cw*06 has a strong influence on the clinical features and the susceptibility to psoriasis in different ethnicities. It is also used as a biomarker to predict the therapeutic efficacy of biologics, with inconsistent results. Additionally, most Asian patients with psoriasis do not carry HLA-Cw*06. Objectives To determine additional HLA alleles which confer susceptibility or affect the severity of psoriasis in Chinese Han individuals. In addition, the potential of using HLA to predict treatment outcomes was also investigated. Methods We conducted a case-control association study in 199 Chinese patients with psoriasis and 200 unrelated healthy controls. HLA-B and HLA-C genotyping was performed and correlated with the therapeutic efficacy of the biologics, including alefacept, efalizumab, etanercept and ustekinumab. Patients with psoriasis were divided into group A (high-need patients with moderate to severe psoriasis) and B (general patients with psoriasis). Results The frequencies of HLA-B*60, HLA-B*75, HLA-Cw*06 and HLA-Cw*10 were significantly increased in patients with psoriasis compared with the healthy controls. However, the prevalence of HLA-Cw*06 was lower in group A compared with group B (6% vs. 17%, Pc = 0·04). HLA-B*46 was found to be strongly associated with group A but not with group B patients with psoriasis. HLA-Cw*01/HLA-B*46 was also identified as a risk haplotype for Chinese patients with psoriasis, compatible with the results in Thais. Significant differences in response to biologics were observed between HLA-Cw*01+ and HLA-Cw*01- individuals in the alefacept treatment group, and between HLA-B*37+ and HLA-B*37-, and HLA-B*58+ and HLA-B*58- individuals in the efalizumab treatment group. Conclusions In addition to HLA-Cw*06, the HLA-Cw*01/HLA-B*46 haplotype was also increased in Chinese patients with psoriasis. High-need patients with psoriasis had a lower frequency of HLA-Cw*06 but a higher prevalence of HLA-B*46 compared with general patients with psoriasis in our population. ? 2011 British Association of Dermatologists.
SDGs
Other Subjects
alefacept; efalizumab; etanercept; HLA B antigen; HLA B46 antigen; HLA B60 antigen; HLA B75 antigen; HLA C antigen; HLA Cw06 antigen; HLA Cw10 antigen; unclassified drug; ustekinumab; adult; article; case control study; Chinese; chronic disease; controlled study; disease severity; drug efficacy; female; genetic difference; genetic susceptibility; genetic variability; genotype; haplotype; human; major clinical study; male; pharmacogenetics; priority journal; prognosis; psoriasis vulgaris; treatment outcome; Adolescent; Adult; Antibodies, Monoclonal; Case-Control Studies; China; Chronic Disease; Dermatologic Agents; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-A Antigens; HLA-B Antigens; HLA-C Antigens; Humans; Male; Polymorphism, Genetic; Psoriasis; Recombinant Fusion Proteins; Risk Factors; Young Adult
Type
journal article