Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells
Journal
ACS Symposium Series
Journal Volume
993
Pages
345-361
Date Issued
2008
Author(s)
Abstract
The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated.
Type
book