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  4. Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101
 
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Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101

Journal
Regulatory Toxicology and Pharmacology
Journal Volume
71
Journal Issue
2
Pages
148-157
Date Issued
2015
Author(s)
SHING-HWA LIU  
TZU-MING PAN  
DOI
10.1016/j.yrtph.2014.11.008
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-84919907090&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/390382
Abstract
The aim of the present work was to assess the genotoxic activity and the potential for toxicity upon repeated dosing of "Vigiis 101" powder, a probiotic consisting of dried bacteria Lactobacillus paracasei subsp. paracasei NTU 101. Results of the Ames test in Salmonella typhimurium strains TA1537, TA98, TA100, TA102, and TA1535 showed that Vigiis 101 (?5. mg per plate) was not mutagenic. We used experiments on ICR mice to evaluate the genotoxicity of Vigiis 101. Compared to the control, high-dose Vigiis 101 administration (16.72. g per kg of body weight) did not cause significant changes either in the number of reticulocytes or in the percentage (occurrence) of micronucleated reticulocytes. A mammalian chromosomal aberration test showed that the number of Chinese hamster ovary cells with abnormal chromosomes was <4% after Vigiis 101 treatment (maximal concentration was 5. mg/ml). A 28-day oral toxicity assay in Wistar rats was performed to assess the no-observed-adverse-effect level of Vigiis 101. Compared to the control, high-dose Vigiis 101 administration (5000. mg/kg/day) had no effects on mortality and body weight and did not cause toxicopathological lesions. Taken together, these results show that Vigiis 101 has no significant mutagenic or toxic effects. ? 2014 Elsevier Inc.
Subjects
Lactobacillus paracasei subsp. paracasei NTU 101; No observed adverse effect level; Probiotic
SDGs

[SDGs]SDG3

Other Subjects
probiotic agent; powder; probiotic agent; Ames test; animal cell; animal experiment; animal tissue; Article; bacterial strain; chromosome aberration; concentration (parameters); controlled study; female; genotoxicity; histopathology; Lactobacillus paracasei; Lactobacillus paracasei subsp paracasei NTU 101; male; micronucleus test; mutagenicity; nonhuman; organ weight; rat; reticulocyte count; safety; Salmonella enterica subsp. enterica serovar Typhimurium; toxicity assay; animal; CHO cell line; Cricetulus; hamster; Institute for Cancer Research mouse; Lactobacillus; mouse; mutagen testing; powder; procedures; Wistar rat; Cricetulus griseus; Lactobacillus paracasei subsp. paracasei; Mammalia; Mus; Rattus norvegicus; Salmonella typhimurium; Animals; CHO Cells; Cricetinae; Cricetulus; Female; Lactobacillus; Male; Mice; Mice, Inbred ICR; Micronucleus Tests; Mutagenicity Tests; Powders; Probiotics; Rats; Rats, Wistar
Type
journal article

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