Impact of Inhaled CO2 on fMRI Experiments and Measurements of Cerebral Vasomotor Reactivity, Cerebral Blood Flow, Cerebral Blood Volume and Cerebral Blood Oxygenation
Date Issued
2007
Date
2007
Author(s)
Juan, Chun-Jung
DOI
en-US
Abstract
The neural activity involves energy demand and energy supply. During neural activation, the energy source glucose and oxygen are supplied by increase cerebral blood flow via a regulation of the cerebral microcirculatory units. In addition to neural activation, the cerebral microcirculation is regulated by many other factors including CO2. It is very likely that the neural activation related cerebral microcirculatory regulation is overwhelmed by the external CO2 perturbation. In this thesis, we explore the effect of inhaled CO2 on cerebral vascular and microcirculatory regulations and on the visual fMRI study.
Specially, we propose a hybrid pulse sequence that allows accurate measurement of cerebral blood volume, cerebral blood flow and cerebral blood oxygenation simultaneously. Experimental results are consistent with prior fMRI and PET studies and the basic understanding of cerebral microcirculatory regulation on physiology.
Subjects
大腦血流量(CBF)
大腦血流體積(CBV)
大腦血流含氧程度(CBO)
功能性磁振造影(fMRI)
磁振造影(MRI)
血管運動反應度(VMR)
cerebral blood flow (CBF)
cerebral blood oxygenation (CBO)
cerebral blood volume (CBV)
functional MRI (fMRI)
hypercapnia
magnetic resonance imaging (MRI)
vasomotor reactivity (VMR)
Type
thesis
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