A non-invasive method using pulse wave transit time to detect propofol-induced kinetic vasodilatation
Date Issued
2012
Date
2012
Author(s)
Lan, Yuan-Chun
Abstract
Anesthesia offers pain relief, muscle relaxation and unconsciousness during surgery. Propofol is the one of the most common used among the anesthetic agents but it results in unavoidable vasodilatation which may lead to lethal consequences in hemodynamically unstable patients. Many methods have been used to detect the complication but they are all invasive. In this thesis, we propose a non invasive method using pulse wave transit time to detect propofol-induced vasodilatation. PTT is the duration of time during which a pulse wave travels between two arterial sites within the same cardiac cycle. It is used to examine propofol’s effects on vascular system. Methods. Data is collected from 70 healthy women, between 28 to 51years old, receiving gynecological surgery under general anesthesia. The general anesthesia was induced with propofol injection (2mg/kg). PTT measurements were obtained from the R wave of electrocardiogram and pulse wave of photoplethysmograph. Two PTT values were obtained; one before (the control) and the other after propofol injection. The results were analyzed by Student''s T-test. Results. After propofol injection, the PTT was prolonged. The change of the PTT value from that of baseline was significant statistically. (P<0.05, by Student’s T-test). The PTT change over time correlated with the degree of vasodilatation over time. PTT monitoring revealed not only the magnitude of vascular changes but also demonstrated the onset of vascular dilation, its peak and duration. We therefore conclude that PTT is a useful guide in monitoring the phamocokinetics of propofol.
Subjects
anesthesia
propofol
PTT
Type
thesis
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