Ti:Al2O3 Crystal-Fiber-Based Parallel Optical Coherence Tomography
Date Issued
2014
Date
2014
Author(s)
Chen, Shang-Tzu
Abstract
Optical coherence tomography (OCT) is one of the most rapidly advancing noninvasive medical imaging modalities that uses coherence gating to obtain tomographic images with micrometer-scale axial resolutions. By detecting the variation of scattering property of biological sample, structural information can be reconstructed. OCT is promising in providing cross-sectional images and 3-D volumetric images of biological tissues in vivo, especially in area where conventional excision examination is impossible or hazardous, such as ophthalmology.
In this study, a non-contact ophthalmoscope and parallel-OCT scanning technique, i.e., full-field OCT (FF-OCT), based on the broadband amplified spontaneous emission of our home-made Ti:Al2O3 single-clad crystal fiber are built and analyzed. With the advantage of the wide bandwidth of the light source and its Gaussian-shape spectrum, a theoretical axial resolution of 1.5 μm is achieved.
In order to demonstrate the feasibility of the developed system in ophthalmology applications, rodent eye scanning is performed in vivo. We have successfully obtained the fundus region imaging, including the optic nerve fibers and optic disk for non-contact ophthalmoscope. The scanning of rat cornea and retina using our FF-OCT system is also demonstrated. The revealed internal layers can be differentiated from the reconstructed cross-sectional images. By comparing our result to that of the histology biopsy, we concur the accordance in the OCT images, showing the potential of this imaging modality in clinical ophthalmology study and applications. We also demonstrate a parallel spectral-domain OCT scanning in its prototype in fingerpad scanning. The line-illumination technique used in this imaging modality provides real-time cross-sectional image that is promising for 3-D volume rendering.
Subjects
同調斷層掃描
Type
thesis
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