Lack of Association between Angiotensin-Converting Enzyme Gene Polymorphism and Peripheral Vascular Disease in Type 2 Diabetic Patients in Taiwan
Resource
CIRCULATION JOURNAL v.66 n.11 pp.1014-1018
Journal
CIRCULATION JOURNAL
Journal Volume
v.66
Journal Issue
n.11
Pages
1014-1018
Date Issued
2002
Date
2002
Author(s)
TSENG, CHIN-HSIAO
Abstract
A total of 361 Chinese patients with type 2 diabetes were studied for the association between peripheral vascular disease (PVD) and the insertion/ deletion polymorphism involving a 287-bp alu repeat sequence at intron 16 of the angiotensin-converting enzyme (ACE) gene. The patients were divided into PVD (+) (n=45) and PVD (-) (n=316) based on an ankle-brachial index <0.9 and greater than or equal to0.9, respectively. Polymerase chain reaction was used to identify gene polymorphism. Results showed that D allele frequency in the patients without and with PVD was 31.8% and 33.3%, respectively (p=NS). The prevalence rates of I[, ID and DD genotypes in the PVD (-) group were 45.6%, 45.3% and 9.2%, respectively; and the respective values for the PVD (+) group were 44.4%, 44.4% and 11.1% (p=NS) . Prevalence rates of PVD in genotypes 11, ID, and DD were 12.2%, 12.3% and 14. 7%, respectively (p=NS). In logistic regression analyses, the unadjusted and adjusted odds ratios for DD vs II and ID vs R genotypes for PVD were not statistically significant. The respective adjusted odds ratios were 1.88 (0.56-6.29) and 1.33 (0.63-2.80). In conclusion, there was not a significant association between the ACE genotype and PVD in Chinese type 2 diabetic patients. However, a type 2 error can not be ruled out.
Subjects
angiotensin-converting enzyme
gene polymorphism
peripheral vascular disease
risk factor
type 2 diabetes mellitus
CORONARY HEART-DISEASE
SDGs
Type
journal article