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Adrenomyeloneuropathy, a Dynamic Progressive Disorder: Brain Magnetic Resonance Imaging of Two Cases
Resource
NEURORADIOLOGY v.46 n.4 pp.296-300
Journal
NEURORADIOLOGY
Journal Volume
v.46
Journal Issue
n.4
Pages
296-300
Date Issued
2004
Date
2004
Author(s)
MO, YUAN-HENG
CHEN, YA-FANG
LIU, HON-MAN
Abstract
Adrenomyeloneuropathy (AMN) is a phenotype variant of X- linked adrenoleukodystrophy. We present two patients with adult-onset AMN who were initially suspected to have demyelinating disorders radiologically and finally diagnosed on the basis of laboratory data. The brain magnetic resonance images showed abnormal signal intensity at pyramidal tracts and cerebellar hemisphere bilaterally with abnormal enhancement after contrast medium administration. Review of the literature shows that the brain magnetic resonance findings of adrenomyeloneuropathy may include normal brain, tract demyelination, white matter demyelination, or brain atrophy. Disease progression was demonstrated by follow-up imaging.
Subjects
adrenomyeloneuropathy
adrenoleukodystrophy
magnetic resonance imaging
demyelination