Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation
Journal
American journal of physiology. Gastrointestinal and liver physiology
Journal Volume
317
Journal Issue
5
Pages
G694-G706
Date Issued
2019
Author(s)
Chien H.-J.
Chiang T.-C.
Peng S.-J.
Chung M.-H.
Chou Y.-H.
Tang S.-C.
Abstract
Modern three-dimensional (3-D) histology with multiplex optical signals identifies the afferent and efferent innervation patterns of human pancreas, which otherwise cannot be defined with standard histology. Our 3-D image data reveal the unexpected association of sensory and parasympathetic nerves/neurons in the intrapancreatic ganglia and identify the sympathetic and parasympathetic nerve contacts with the infiltrated adipocytes. The multiplex approach offers a new way to characterize the human pancreas in remodeling (e.g., fatty infiltration and duct lesion progression).
SDGs
Publisher
NLM (Medline)
Type
journal article