1H Magnetic Resonance Imaging in Pulmonary Perfusion: Techniques and Applications
Date Issued
2006
Date
2006
Author(s)
Lin, Yi-Ru
DOI
en-US
Abstract
Pulmonary perfusion is a fundamental parameter of lung function, since matched distribution of the regional pulmonary blood flow and ventilation is a prerequisite for gas exchange to occur efficiently. Radionuclide techniques using intravenous administration of radioactive macroaggregates have been used for the clinical assessment of regional lung perfusion. Recently, magnetic resonance imaging has become feasible using ultra-short echo time sequence. In this thesis, we present recent advances in magnetic resonance pulmonary perfusion imaging, including magnetic resonance perfusion imaging using gadolinium contrasts agents (CE-MRI) or spin labeling of blood using naturally flowing spins as the source of intravascular signal (ASL). First, we apply flow-sensitive alternating inversion recovery (FAIR) and CE-MRI techniques in normal subjects, and demonstrate that FAIR imaging for pulmonary perfusion in the coronal plane provides equivalent rPBF information with CE-MRI only in the absence of tracer saturation effects, hence, FAIR should be carefully exercised to avoid misleading interpretations. Second, we show that discrepancy exists between lung perfusion scintigraphy (PS) and CE-MRI, resulted from the abnormal flow dynamic in patients with complex cardiovascular circulation such us patients with congenital heart diseases. A remedy using limited integration has been proposed, which provides consistent perfusion result as PS. We conclude that CE-MRI is facilitate in pulmonary perfusion and has significant potential for clinical use.
Subjects
磁振造影
肺部微灌流影像
對比劑顯影磁共振影像
動脈標記法
Magnetic Resonance Imaging
MRI
pulmonary perfusion
contrast-enhanced MRI
arterial spin labeling
Type
thesis
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