Aging and Renal Disease: Old Questions for New Challenges
Journal
Aging and disease
Journal Volume
12
Journal Issue
2
Date Issued
2021-04
Author(s)
Abstract
Chronic kidney disease (CKD) is a growing problem among aging population, and the number of individuals at risk of end stage renal disease is rising. Part of the reason lies in incomplete understanding of the pathways underlying renal aging and kidney disease, as well as insufficient delivery of evidence-based treatment to elderly patients with CKD. This review aims to address these unsolved issues by delineating updated mechanisms of renal senescence and summarizing recent findings on key clinical aspects of CKD in the elderly. Challenges and obstacles in caring for older people with CKD are discussed, with an emphasis on modification of risk factors, prevention of acute kidney injury, stabilization of progression and decision on dialysis initiation.
Subjects
acute kidney injury; aging; chronic kidney disease; dialysis; elderly; end stage renal disease
Acute kidney injury; Aging; Chronic kidney disease; Dialysis; Elderly; End stage renal disease
SDGs
Other Subjects
angiotensin 1 receptor antagonist; angiotensin receptor antagonist; angiotensinogen; atorvastatin; atrial natriuretic factor; baicalin; beta catenin; catalase; creatinine; cryopyrin; cytochrome c oxidase; enalapril; glutathione; glutathione reductase; hemoglobin A1c; hydroxymethylglutaryl coenzyme A reductase inhibitor; hypoxia inducible factor; immunoglobulin enhancer binding protein; inflammasome; interleukin 18; interleukin 1beta; interleukin 6; interleukin 8; Klotho protein; losartan; nitric oxide; nitric oxide synthase; pentoxifylline; peroxisome proliferator activated receptor gamma; phosphoribosyltransferase; pioglitazone; protein p21; protein p53; quercetin; reactive oxygen metabolite; sirtuin; sirtuin 3; sodium glucose cotransporter 2; superoxide dismutase; tumor necrosis factor; acute kidney failure; aged; aging; cardiovascular disease; care behavior; chronic inflammation; chronic kidney failure; clinical feature; daily life activity; disease exacerbation; DNA sequence; dyslipidemia; end stage renal disease; fibrogenesis; gene knockdown; glomerulosclerosis; glomerulus basement membrane; hemodynamics; hospitalization; human; hypotension; kidney blood flow; kidney disease; kidney donor; kidney function; kidney ischemia; kidney polycystic disease; kidney tissue; life expectancy; nephrosclerosis; nephrotoxicity; obesity; oral glucose tolerance test; oxidative stress; palliative therapy; prevalence; protein expression; proteinuria; quality of life; regulatory T lymphocyte; renal replacement therapy; Review; risk factor; senescence; sepsis; signal transduction; sodium restriction; telomere length; telomere shortening; upregulation; urolithiasis; Wnt signaling
Type
review