三酸甘油酯過高病人之治療對低密度脂蛋白及高密度脂蛋白細分類, 以及內皮細胞功能之影嚮
Other Title
The effects of treatment of hypertriglyceridemia on the subfractions of LDL
and HDL and the endothelial function
and HDL and the endothelial function
Date Issued
2003
Date
2003
Author(s)
廖朝崧
DOI
912314B002282
Abstract
Hypertriglyceridemia is a very common lipid disorder in Chinese. The role of high serum
triglyceride (TG) in atherosclerosis has been controversial for a long time, but recently it has been
widely accepted that TG is definitely an independent risk factor for atherosclerosis.
Hypertriglyceridemia is one important component of metabolic syndrome. TG-rich lipoproteins
have been identified highly atherogenic in humans. We studied the effects of
hypertriglyceridemia on in vitro mononuclear cell adhesion to cultured human endothelial cells
and the in vivo endothelial function by using brachial artery flow mediated dilatation method. A
total of 90 patients with 122 tests were completed. Thirty patients had 2 studies. We found that
after intervention the patients had their lipid profile markedly changed with reduction of TG and
increase of HDL-C. The mononuclear cell adhesion was found not correlated with serum TG
level but could be affected by LDL-C level. Patients with high TG levels had impaired
endothelial function which was found improved after reduction of the serum TG levels. It was
concluded that TG was not an important factor in determining the adhesion of mononuclear cells
to endothelial cells but LDL-C was. Hypertriglyceridemia could significantly affect the
endothelial function through impairment of flow-mediated vasodilatation.
Subjects
hypertriglyceridemia
atherosclerosis
diabetes mellitus
low density lipoprotein
low
density lipoprotein subclass
density lipoprotein subclass
high density lipoprotein
high density lipoprotein subclass
endothelial function
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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