Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs
Journal
Pigment Cell and Melanoma Research
Journal Volume
27
Journal Issue
4
Pages
668-670
Date Issued
2014
Author(s)
Baco M.
Chu C.-ying.
Bouet S.
Rogel-Gaillard C.
Bourneuf E.
Le Provost F.
Vincent-Naulleau S.
Abstract
Treatment of advanced cutaneous melanoma is still challenging and new data on melanoma biology are required. MicroRNAs (miRNAs) represent an emerging field in melanoma understanding. These small regulators of gene expression, involved in melanoma development and progression (Da cruz et al., 2012), showed promising results as biomarkers (Nair et al., 2012). As each miRNA could regulate multiple protein-coding genes and conversely, one gene could be targeted by different miRNAs (Bartel et al., 2009), the dysregulation of miRNAs could significantly impact various pathways and cells behavior.
Publisher
Blackwell Publishing Ltd
Type
journal article