Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract
Journal
Biochimica et Biophysica Acta - Gene Structure and Expression
Journal Volume
1492
Journal Issue
1
Pages
196-202
Date Issued
2000
Author(s)
Abstract
We isolated the cDNA of a novel platelet-derived growth factor-like gene from human endometrium. The gene was named fallotein; it was 3007 bases in length, and encoded a protein of 345 amino acids. Antiserum against the fallotein protein can recognize a specific protein in the fallopian tube, with a molecular size in accordance with the anticipated size of fallotein. Fallotein mRNA is expressed in two molecular sizes, 3.8 and 2.9 kb, with the former being more abundant. High expression of the gene was found in the prostate, testis, and uterus. A weaker expression signal was found in the spleen, thymus, and small intestine, but expression of fallotein in the colon and peripheral blood leukocytes was negligible.
Type
journal article