Mixed infections of hepatitis c virus as a factor in acute exacerbations of chronic type c hepatitis
Journal
Journal of Infectious Diseases
Journal Volume
170
Journal Issue
5
Pages
1128-1133
Date Issued
1994
Author(s)
Abstract
Twenty patients with chronic hepatitis C virus (HCV) infection and acute exacerbations (group A) were studied by polymerase chain reaction with genotype-specific primers to explore the role of mixed infections of HCV in acute exacerbations of chronic type C hepatitis. Another 26 patients who did not have acute exacerbation were matched controls (group B). Eleven (55%) of the group A patients had heterologous HCV, and their mean age was significantly younger than that of the 9 without heterologous infection (55 vs. 67 years, P <.05). In contrast, only 2 group B patients (7.7%) had heterologous HCV infection. In 10 of 13 patients with heterologous HCV infection, type III/2a virus emerged on type II/1b HCV, and viral interference was observed in half of them. The results support that mixed infections of HCV may be important in acute exacerbations of chronic type C hepatitis. ? 1994 by The University of Chicago.
SDGs
Other Subjects
adult; aged; article; chronic disease; clinical article; female; genetic heterogeneity; genotype; hepatitis c virus; human; liver biopsy; male; mixed infection; molecular cloning; polymerase chain reaction; priority journal; superinfection; virus genome; virus infection; virus transmission; Acute Disease; Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Genotype; Hepacivirus; Hepatitis C; Human; Male; Middle Age; Polymerase Chain Reaction; Support, Non-U.S. Gov't
Type
journal article