臺灣地區從醫院病患分離出Chlorhexidine抗藥性金黃色葡萄球菌菌株之分子流行病學、臨床特質及chlorhexidine抗藥性機轉的研究
Other Title
Emergence of Reduced Chlorhexidine Susceptibility in
Methicillin-Resistant Staphylococcus aureus at a Teaching Hospital
Methicillin-Resistant Staphylococcus aureus at a Teaching Hospital
Date Issued
2005
Date
2005
Author(s)
盛望徽
DOI
932314B002080
Abstract
We studied the chlorhexidine susceptibility, molecular typing, and the
distribution of the qacA/B gene of methicillin-resistant Staphylococcus aureus
(MRSA) isolates obtained in 1990, 1994, 1995, and 2002 at the National Taiwan
University Hospital (NTUH). The prevalence rate of MRSA with a high minimum
inhibitory concentration (MIC) of chlorhexidine (≧4 μ g/mL) was found to increase
rapidly during this 13-year period, from 3.3% in 1990 to 66.7% in 2002. Nearly all of
the MRSA isolates with high chlorhexidine MICs carried the qacA/B gene and
belonged to a single molecular type. The prevalence rate of MRSA isolates with high
chlorhexidine MIC correlates well with that of MRSA isolates belonging to the
molecular type. We conclude that the prevalence rate of MRSA with high
chlorhexidine MIC increased rapidly during past 13 years at the NTUH, which was
associated with an endemic strain, carrying the qacA/B gene, spreading in the
hospital.
Subjects
methicillin-resistant Staphylococcus aureus
MRSA
chlorhexidine
pulsed-field gel electrophoresis
qacA/B
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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