HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase
Journal
Oncogene
Journal Volume
33
Journal Issue
38
Pages
4643-4652
Date Issued
2014
Author(s)
Tsai C.-H.
Teng C.-H.
Tu Y.-T.
Cheng T.-S.
Wu S.-R.
Shyu H.-Y.
Lan S.-W.
Tzeng S.-F.
Johnson M.D.
Lin C.-Y.
Hsiao P.-W.
Abstract
Dysregulation of cell surface proteolysis has been strongly implicated in tumorigenicity and metastasis. In this study, we delineated the role of hepatocyte growth factor activator inhibitor-2 (HAI-2) in prostate cancer (PCa) cell migration, invasion, tumorigenicity and metastasis using a human PCa progression model (103E, N1, and N2 cells) and xenograft models. N1 and N2 cells were established through serial intraprostatic propagation of 103E human PCa cells and isolation of the metastatic cells from nearby lymph nodes. The invasion capability of these cells was revealed to gradually increase throughout the serial isolations (103E
SDGs
Other Subjects
membrane protein; serine proteinase; SPINT2 protein, human; ST14 protein, human; animal; article; cancer transplantation; carcinogenesis; cell motion; enzymology; gene expression regulation; genetics; human; lung tumor; lymph node metastasis; male; metabolism; metastasis; mouse; nude mouse; pathology; physiology; prostate tumor; tumor invasion; tumor volume; Animals; Carcinogenesis; Cell Movement; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Membrane Glycoproteins; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Prostatic Neoplasms; Serine Endopeptidases; Tumor Burden
Publisher
Nature Publishing Group
Type
journal article