Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression
Journal
Oncotarget
Journal Volume
8
Journal Issue
37
Pages
61901-61916
Date Issued
2017
Author(s)
Chen Y.-Y.
Chen J.J.W.
Abstract
value. Immunohistochemical staining of clinical biopsy samples showed that patients with lower AEG-1 expression had longer overall survival time. Moreover, analysis of repeated biopsy samples revealed that an increase in the TS level from baseline to disease progression was significantly associated with the elevation of AEG-1 expression. In conclusion, our data demonstrated that TS expression might be regulated by AEG-1 and that increased expression of these proteins contributes to lung cancer disease progression and may be associated with the development of resistance to pemetrexed.
SDGs
Publisher
Impact Journals LLC
Type
journal article