IL-6 induces periostin production in human ACL remnants: a possible mechanism causing post-traumatic osteoarthritis
Journal
Journal of orthopaedic surgery and research
Journal Volume
18
Journal Issue
1
Date Issued
2023-11-02
Author(s)
Abstract
Perostin (POSTN) and IL-6 consistently elevated after ACL injury, and ACL has been proposed as the major source of POSTN. However, there is a lack of evidence whether IL-6 induces ACL remnants to produce POSTN. This study aimed to investigate the effect of IL-6 on POSTN production in ACL fibroblasts, which may help us understand more about the mechanism of PTOA after ACL injury and ACL reconstruction.
Subjects
ACL; IL-6; Osteoarthritis; Periostin; Reconstruction
Type
journal article