Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones
Journal
European Journal of Medicinal Chemistry
Journal Volume
50
Pages
102-112
Date Issued
2012
Author(s)
Lee C.-C.
Huang K.-F.
Chang D.-M.
Hsu J.-J.
Huang F.-C.
Shih K.-N.
Chen C.-L.
Chen T.-C.
Chen R.-H.
Huang H.-S.
Abstract
A series of symmetrical disubstituded 1,8-diamidoanthraquinones were synthesized and evaluated for anti-proliferation, telomerase inhibitory by TRAP assay, and hTERT expression by SEAP assay. All of the compounds tested, except for compounds 3a and 3s were selected by the NCI screening system. In addition, compounds 4e and 4k exhibited inhibitory effects on telomerase activity. Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase targeting strategy.
Type
journal article