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  4. Mortality association between obesity and pneumonia using a dual restricted cohort model
 
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Mortality association between obesity and pneumonia using a dual restricted cohort model

Journal
Obesity Research and Clinical Practice
Date Issued
2019-01-01
Author(s)
HAO-CHIEN WANG
CHIEN-CHANG LEE  
Chou, Eric H.
Hsu, Wan Ting
Robinson, Richard D.
Su, Ke Ying
Kirby, Jessica J.
Hassani, Dahlia
DOI
10.1016/j.orcp.2019.10.001
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/431112
URL
https://api.elsevier.com/content/abstract/scopus_id/85073717439
Abstract
© 2019 Asia Oceania Association for the Study of Obesity Background: An obesity survival paradox has been reported among obese patients with pneumonia. Aims: To determine the impact of obesity on pneumonia outcomes and analyze the correlation between in-hospital all-cause mortality and obesity among patients with pneumonia. Methods: The United States Nationwide Readmissions Database (NRD) was retrospectively analyzed for patients with pneumonia from 2013 to 2014. We used a step-wise restricted and propensity score matching cohort model (dual model) to compare mortality rates and other outcomes among pneumonia patients based on BMI. Mortality was calculated by a Cox proportional hazard model, adjusted for potential confounders with propensity score matched analysis. Results: A total of 70,886,775 patients were registered in NRD during the study period. Of these, 7,786,913 patients (11.0%) were considered obese and 1,652,456 patients (2.3%) were admitted to the hospital with pneumonia. Based on the step-wise restricted cohort model, the hazard ratio comparing the mortality rates among obese pneumonia patients to mortality rates among normal BMI pneumonia patients was 0.75 (95% CI 0.60–0.94). The propensity score matched analysis estimated a hazard rate of 0.84 (95% CI 0.79–0.90) and the hazard ratio estimated from the dual model was 0.82 (95% CI 0.63–1.07). Conclusions: With the application of a dual model, there appears to be no significant difference in mortality of obese patients with pneumonia compared to normal BMI patients with pneumonia.
Subjects
Mortality | Obesity | Pneumonia
Mortality; Obesity; Pneumonia
SDGs

[SDGs]SDG3

Other Subjects
adult; aged; all cause mortality; Article; body mass; cohort analysis; confidence interval; controlled study; data base; disease association; female; hazard ratio; human; major clinical study; male; middle aged; mortality rate; obesity; pneumonia; priority journal; propensity score; proportional hazards model; retrospective study; very elderly; young adult; adolescent; comorbidity; epidemiology; factual database; hospital mortality; mortality; obesity; pneumonia; reproducibility; risk factor; survival analysis; theoretical model; United States; Adolescent; Adult; Aged; Aged, 80 and over; Cohort Studies; Comorbidity; Databases, Factual; Female; Hospital Mortality; Humans; Male; Middle Aged; Models, Theoretical; Obesity; Pneumonia; Reproducibility of Results; Retrospective Studies; Risk Factors; Survival Analysis; United States; Young Adult
Type
journal article

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