Hepatitis B virus DNA levels and outcomes in chronic hepatitis B
Other Title
Wu MH
Resource
HEPATOLOGY,49(5 SUPPL. S),S72-S84.
Journal
Hepatology
Pages
S72-S84
Date Issued
2009
Date
2009
Author(s)
CHEN, CHIEN-JEN
YANG, HWAI-I
Iloeje UH
REVEAL-HBV Study Group
Liaw YF
Jen CL
You SL
Chen TH
Lu SN
Yeh SH
Sun CA
Chen SY
Ho SC
Lu TG
Chen CC
Chen DS
Chen PJ
Hsieh CY
Lee HS
Yang PM
Chen CH
Chen JD
Huang SP
How WC
Su J,
Wu WP
Ou TY
Shih KC
Chung WS
Li C
Lin CG
Wang LY
Chu KE
Abstract
Serum hepatitis B virus (HBV) DNA levels can fluctuate markedly during the course of chronic HBV infection. Both case-control and cohort studies have shown a significant, dose-response association between serum HBV DNA levels measured at the time of initial evaluation and the subsequent risk of cirrhosis. A similar direct relationship has been shown for the risk of hepatocellular carcinoma (HCC) in cross-sectional, case-control, and cohort studies. Interventional studies have shown a strong correlation between the indices of disease activity seen on liver biopsy and levels of serum HBV DNA. These studies have also shown that reduction in HBV DNA levels correlate strongly with improvements in liver histology. For patients with HCC, prognosis (including risk of death, metastasis, and recurrence following surgery) is worse with higher serum HBV DNA levels. The preponderance of the evidence in the published literature demonstrates that serum HBV DNA level is an important and independent risk factor for disease progression in chronic hepatitis B. The relative importance of serial HBV DNA measurements, the loss of hepatitis B e and surface antigens, as well as the emergence of HBV mutants in the progression of chronic hepatitis B, especially in young patients, is an important need for future research. ? 2009 American Association for the Study of Liver Diseases.
SDGs
Other Subjects
hepatitis B surface antigen; hepatitis B(e) antigen; virus DNA; virus DNA; adult; article; cohort analysis; death; disease activity; disease course; female; hepatitis B; Hepatitis B virus; human; liver biopsy; liver cell carcinoma; liver cirrhosis; liver histology; male; metastasis; nonhuman; priority journal; prognosis; recurrence risk; risk assessment; risk factor; virus mutant; blood; conference paper; consensus development; genetics; growth, development and aging; hepatitis B; virology; DNA, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Risk Factors
Type
journal article