MR imaging-based intracranial pressure estimation: reproducibility and contributions of in-plane CSF flow.
Date Issued
2012
Date
2012
Author(s)
Wu, Yi-Ying
Abstract
Currently the ICP measurement method performed in clinical practice is a highly invasive technique. An external pressure detector has to be placed in the central nervous system such as lateral ventricle or lumbar spine for monitoring the pressure changes. However, the continuous ICP monitoring is usually accompanied by risks including possible infections. In addition, in the surgical procedure may impose potential morbidity for the patients. These considerations drive investigators to develop noninvasive techniques for ICP estimation.
Previous studies have proposed noninvasive cine phase-contrast MRI method to estimate the ICP and its related indices, ICC and ICE, based on blood / CSF volumetric flow rates and CSF pressure gradient. In this study, we attempted to repeat this accepted measurement method to assess its precision level on healthy subjects, and at the same time verify the validity of some simplified assumptions
practically in order to get more comprehensive estimation as well as provide clearer clinical significance.
Subjects
MR-intracranial pressure
intracranial compliance
intracranial elastance
cerebrospinal fluid dynamic
phase contrast magnetic resonance imaging
Type
thesis
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