EFFECT OF DEPTH OF INHALATION ON AEROSOL PERSISTENCE DURING BREATH HOLDING
Resource
JOURNAL OF APPLIED PHYSIOLOGY v.34 n.3
Journal
JOURNAL OF APPLIED PHYSIOLOGY
Journal Volume
v.34
Journal Issue
n.3
Pages
-
Date Issued
1973
Date
1973
Author(s)
CHUA, JESUS-HUAN
WANG, CHIU-SEN
Abstract
To determine the effect of depth of inhalation on aerosol persistence in the respiratory tract during breath holding, an aerosol bolus was inhaled, followed by 200-800 ml of clean air to a lung volume slightly below TLC. The breath was then held from 0.5 to 20 sec, after which a forced exhalation was made and aerosol recovery was measured as a fraction of that inhaled. In this way persistence was measured as a function of inhaled volume and of time of breath holding for six normal subjects. The bolus results were then compared with those for complete aerosol inhalations in which persistence was measured in the same way. Results on each subject by the two procedures agreed well, but there were considerable differences between subjects. It was concluded that depth of inhalation has a greater effect on persistence than would be predicted from some current lung models.#B0173036
Subjects
微粒肺部沈積
AEROSOL PHYSIOLOGY
AEROSOL BOLUS
AIR- SPACE DIMENSIONS
LUNG STRUCTURE
DEPOSITION OF INHALED PARTICLES
Type
journal article