A natural allele of Nxf1 suppresses retrovirus insertional mutations
Resource
Nature Genetics 35: 221-228
Journal
Nature Genetics
Journal Volume
35
Journal Issue
3
Pages
221-228
Date Issued
2003
Date
2003
Author(s)
Floyd, Jennifer A
Gold, David A
Concepcion, Dorothy
Poon, Tiffany H
Wang, Xiaobo
Keithley, Elizabeth
Chen, Dan
Ward, Erica J
Chinn, Steven B
Friedman, Rick A
Moriwaki, Kazuo
Shiroishi, Toshihiko
Hamilton, Bruce A
Abstract
Endogenous retroviruses have shaped the evolution of mammalian genomes. Host genes that control the effects of retrovirus insertions are therefore of great interest. The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpnvb tremor mutation and the Eya1 BOR model of human branchiootorenal syndrome. Positional complementation cloning identifies Mvb1 as the nuclear export factor Nxf1, providing an unexpected link between the mRNA export receptor and pre-mRNA processing. Population structure of the suppressive allele in wild Mus musculus castaneus suggests selective advantage. A congenic Mvb1CAST allele is a useful tool for modifying gene expression from existing mutations and could be used to manipulate engineered mutations containing retroviral elements.
Other Subjects
messenger RNA; messenger RNA precursor; nuclear export factor i; nuclear factor I; unclassified drug; allele; animal experiment; animal tissue; article; branchiootorenal syndrome; controlled study; evolution; eya1 bor gene; eya1 gene; gene control; gene expression regulation; gene insertion; gene locus; genetic complementation; intron; modifier of vibrator 1 gene; mouse; mvb1 case gene; nonhuman; pitpn gene; pitpn vb gene; priority journal; Retrovirus; RNA processing; RNA splicing; transgene; virus genome; virus mutation; Alleles; Amino Acid Sequence; Animals; DNA-Binding Proteins; Endogenous Retroviruses; Genetic Complementation Test; Humans; Introns; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagenesis, Insertional; Sequence Homology, Amino Acid; Transcription Factors; Transgenes; Animalia; insertion sequences; Mammalia; Mus; Mus musculus; Mus musculus castaneus; Musculus; RNA viruses; unidentified retrovirus
Type
journal article
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